Koi Care Kennel PraziPond Plus is USP grade (99.5% pure) prazi blended with cyanocobalamin and a proprietary polymer mixture. Praziquantel ("Prazi") is the preeminent treatment for flukes. 'Prazi' is by far the most gentle, yet effective treatment for flukes available to our hobby. No other prazi available today has this advanced formula. PraziPond Plus is 40% more effective than prazi alone. PraziPond Plus is manufactured for Koi Care Kennel, Inc. by AquaScience Research Group, Inc., the leading company in the koi hobby for polymer advanced research. AquaScience's polymers are responsible for the success of "ProForm-C" and "Ultimate Water Conditioner". Now AquaScience's advanced polymer technology is available in PraziPond Plus. As a preventative, we recommend treating once a year in early Spring. PraziPond Plus will work in ANY water temperture, and can be used at the same time with ProForm-C. A Non-Diversion Certificate is required to purchase.